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Myoepithelial carcinoma / Models

Cell lines and research models

What a laboratory can work with today. It is a short list.

Updated 11 November 2026. Not medical advice.

On this page
  1. Cell lines
  2. Organoids, xenografts and other models
  3. Datasets and codes
  4. The gap
  5. References

1Cell lines

Cellosaurus, the reference catalog of cell lines, lists 4 lines derived from myoepithelial tumors. 1 of them come from a malignant myoepithelial tumor1.

LineAccessionDerived fromKindNote
HMS-4CVCL_UD68Breast malignant myoepitheliomaCancer cell lineMalignant
METONCVCL_T055Salivary gland myoepitheliomaCancer cell lineBenign
CEM 2clCVCL_Y484Salivary gland epithelial-myoepithelial carcinomaCancer cell lineA different diagnosis
UTSW-EMC23CVCL_Y491Salivary gland epithelial-myoepithelial carcinomaTransformed cell lineA different diagnosis

2Organoids, xenografts and other models

cureMEC reports building the first preclinical models of the disease, including for the EWSR1 fusion-positive form23.

AccessionStudy
PRJDB10974Establishment of salivary gland cancer organoids and Patient-derived xenograft models

3Datasets and codes

Sequencing and expression datasets, standard codes and federal funding are listed in the researcher section of the main page. Exome and RNA sequencing from 27 patients is in the EGA archive4, and the raw reads behind the 2017 genomic study are in BioProject PRJNA3906105.

4The gap

A disease with one malignant cell line in the reference catalog cannot be studied the way common cancers are. Tissue from patients is how that changes. Patients can ask their surgeon whether tissue can be banked for research, and cureMEC is building biospecimen collections2.

5References

  1. Cellosaurus, SIB Swiss Institute of Bioinformatics. Cell lines with a myoepithelial tumor as the disease of origin, retrieved 11 November 2026. source ↩
  2. Jamie D. Barber, Naomi Natale, Michael Casaus. Abstract 6355: Building the first comprehensive research ecosystem and preclinical model platform for myoepithelial carcinoma. Cancer Research, 2026. DOI ↩
  3. Jamie D. Barber, Barbara Van Hare, Naomi Natale et al. Abstract A004: Establishing the First Integrated Research Infrastructure and Preclinical Models for EWSR1 Fusion-Positive Myoepithelial Carcinoma. Cancer Research, 2026. DOI ↩
  4. Kashyap M, Wright H, Byun J et al. Genomic Landscape of Myoepithelial Carcinoma Tumors. Oral diseases, 2026. PubMed ↩
  5. Dalin MG, Katabi N, Persson M et al. Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. Nature communications, 2017. PubMed ↩